Sodium cyanoborohydride is the chemical compound with the formula NaBH3CN,widely used in organic synthesis for the reduction of imines
Name: Sodium cyonoborohydride; Sodium cyanotrihydridoborate; Sodium borocyanohydride
Appearance: white powder
Package: 100g, 500g, 1Kg, 25Kg
Availability: 1000Kgs in stock
Applications: proton source; reducing agent.
Sodium cyanoborohydride is the chemical compound with the formula NaBH3CN. It is a colourless salt, but commercial samples can appear tan. It is widely used in organic synthesis for the reduction of imines. The salt tolerates aqueous conditions.
Owing to the presence of the electron-withdrawing cyanide substituent, [B(CN)H3]− is far less reducing than is [BH4]−, as found in sodium borohydride. As a mild reducing agent, it is especially used to convert imines to amines.
It is especially favored for reductive aminations, wherein aldehydes or ketones are treated with an amine in the presence of this reagent:
The reagent is typically used in excess. Selectivity is achieved at mildly basic solutions (pH 7-10). The reagent is ideal for reductive aminations ("Borch Reaction"). In conjunction with tosylhydrazine, sodium cyanoborohydride is used in the reductive deoxygenation of ketones.
Sodium cyanoborohydride is a milder reductant and a less toxic alternative, but highly unstable in water.
Sodium cyanoborohydride could be supplied with the capacity of 10metric tones per month.