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10-Carboxymeth-9-acridanone 38609-97-1 Supplied With Competitive Price

10-Carboxymeth-9-acridanone 38609-97-1 Supplied With Competitive Price

Name: 10-Carboxymeth-9-acridanone ; N-(Carboxymethyl)acridone ; 9-Oxo-10(9H)-acridineacetic acid ; (9-Oxo-10(9H)-acridinyl)acetic acid; Acridone acetic acid; 10-Carboxymethylacridin-9(10H)-one; Cridanimod; 10(9H)-acridineacetic acid, 9-oxo- CAS: 38609-97-1 EINECS: N/A MF: C 15 H 11 NO 3 MW:...

    Name: 10-Carboxymeth-9-acridanone; N-(Carboxymethyl)acridone ; 9-Oxo-10(9H)-acridineacetic acid; (9-Oxo-10(9H)-acridinyl)acetic acid; Acridone acetic acid; 10-Carboxymethylacridin-9(10H)-one; Cridanimod; 10(9H)-acridineacetic acid, 9-oxo-

    CAS: 38609-97-1

    EINECS: N/A

    MF: C15H11NO3

    MW: 253.25

    Appearance: yellow crystal powder

    Purity: 99%min.(HPLC)

    Melting point: ~289 °C (dec.) (lit.)

    Package: 1Kg, 5Kg, 25Kgs

    Price: USD90-210/1Kg

    Availability: regular product, in stock under 1000Kgs

    Applications: pharmaceutical intermediate

     

    Cridanimod is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy.

      10-Carboxymeth-9-acridanone CAS: 38609-97-1 is precausor of Camedon, a yellow crystal powder, which is also named as N-(Carboxymethyl)acridone ; 9-Oxo-10(9H)-acridineacetic acid; (9-Oxo-10(9H)-acridinyl)acetic acid; Acridone acetic acid; 10-Carboxymethylacridin-9(10H)-one; Cridanimod; 10(9H)-acridineacetic acid, 9-oxo-. Its precausor is acridin-9-(10H)-one CAS:578-95-0.


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